ETIDIOH - NEW

  Abstract Background :  In Mexico, two Mammarenavirus genotypes have been identified : Real de Catorce virus and Ocozocoautla de Espinosa virus (OCEV), which are found in rodents (Neotoma leucodon and Peromyscus mexicanus). Mammarenaviruses from clade B cause mild to severe infectious diseases in humans , particularly in South America. A 1967 outbreak in Chiapas, Mexico, was potentially linked to the OCEV. Materials and Methods :  Between 2017 and 2020, we collected bats across southern/southeastern Mexico to identify Mammarenavirus reservoirs. We analyzed 81 liver samples from 14 bat species using nested PCR. For quality control, we synthesized and OCEV S-region fragment into an ampicillin-resistant pUC57 plasmid, cloned in One Shot Stbl3 chemically competent E. coli. Results :  Here, we report the first detection of a Mammarenavirus (OCEV) in an Artibeus lituratus bat from Sabancuy, Campeche , southeastern Mexico. This finding represents the third Mammarenavirus r...

  Abstract Background On September 27, 2024, Rwanda reported an outbreak of Marburg virus disease (MVD), after a cluster of cases of viral hemorrhagic fever was detected at two urban hospitals. Methods We report key aspects of the epidemiology, clinical manifestations, and treatment of MVD during this outbreak, as well as the overall response to the outbreak. We performed a retrospective epidemiologic and clinical analysis of data compiled across all pillars of the outbreak response and a case-series analysis to characterize clinical features, disease progression, and outcomes among patients who received supportive care and investigational therapeutic agents. Results Among the 6340 patients with suspected MVD who underwent testing, 66 had laboratory-confirmed MVD , 51 (77%) of whom were health care workers. The median estimated incubation period was 10 days (interquartile range, 8 to 13), and symptom onset occurred a median of 2 days (interquartile range, 1 to 3) before hospital ad...