ETIDIOH - NEW

  Am J Respir Crit Care Med NAQVI ZA Residual Scars That Grow: The Hidden Threat of Delayed Pulmonary Fibrosis Post-COVID-19. Am J Respir Crit Care Med. 2025 Aug 22. doi: 10.1164/rccm.202506-1558. PubMed          BALDWIN MR, Garcia CK Reply to Naqvi: Residual Scars That Grow: The Hidden Threat of Delayed Pulmonary Fibrosis Post-COVID-19. Am J Respir Crit Care Med. 2025 Aug 22. doi: 10.1164/rccm.202507-1624. PubMed          Antiviral Res TERATAKE Y, Okamura T, Ishizaka Y SMAD5 phosphorylation by ALK1 is modulated by the interaction of the spike protein of SARS-CoV-2 and angiotensin-converting enzyme 2. Antiviral Res. 2025;242:106261. PubMed           Abstract available GOLDIN K, Brackney B, Lutterman T, Williamson BN, et al Dexamethasone treatment does not alter mortality but reduces pulmonary pathology in Nipah virus-infected Syrian hamsters. Antiviral Res. 2025;242:106263....

  Antiviral Res GUAN S, Wang Q, Nie J, Yao X, et al Optimization of the monoclonal antibody 3E1 through W32I mutation enhances antiviral efficacy against influenza virus subtypes H1N1 and H3N2. Antiviral Res. 2025;242:106260. PubMed           Abstract available Biochem Biophys Res Commun GABELMANN A, Biesel A, Loretz B, Lehr CM, et al Exploring the future of mRNA delivery: Beyond lipid nanoparticles. Biochem Biophys Res Commun. 2025;778:152347. PubMed           Abstract available Biochemistry SUBRAMANIAM S, Saville JW, Feng F, Freiburger L, et al Therapeutic Antibodies for Infectious Diseases: Recent Past, Present, and Future. Biochemistry. 2025;64:3487-3494. PubMed           Abstract available Epidemiol Infect CHOI H, Hwang M, Coppin JD, Chatterjee P, et al Penetration of SARS-CoV-2 Alpha, Delta, and Omicron variants in the United States. Epidemiol Infect. 2025;1...

  ABSTRACT Influenza A virus (IAV) in swine in the U.S. is surveilled to monitor genetic evolution to inform intervention efforts and aid pandemic preparedness . We describe data from the U.S. Department of Agriculture National Surveillance Plan for Influenza A Virus in Pigs from 2009 to 2022. Clinical respiratory cases were subtyped, followed by sequencing of hemagglutinin (HA) and neuraminidase (NA), and a subset of viruses was whole genome sequenced . Phylogenetic analysis identified geographic and temporal IAV reassortment hotspots . Regions acting as IAV genomic diversity sources or sinks were quantified, and dissemination was qualified and modeled. The dominant IAV clades were H1N2 (1B.2.1), H3N2 (1990.4.a), and H1N1 (H1-1A.3.3.3-c3). Internal genes were classified as triple-reassortant (T) or pandemic 2009 (P), and three genome constellations represented 73.5% of detections across the last 2 years. In some years, the distribution of IAV diversity was so narrow that it presen...

  Poultry farms in Plovdiv Region. Source: WOAH,  https://wahis.woah.org/#/in-review/6746 ____

  Abstract Background :  Flaviviruses represent a significant worldwide threat to human health and have the potential to emerge and cause outbreaks in non-endemic geographical regions. Ongoing surveillance for these viruses in the United States–Mexican border communities such as El Paso, Texas , is lacking. As a continuing effort to better understand the prevalence and to determine which arboviruses are endemic, the aim of this study was to determine the prevalence rate of specific flavivirus antibody among 910 human umbilical cord blood samples obtained from mothers who delivered newborns in El Paso, Texas. Materials and Methods :  The samples were screened for West Nile virus (WNV) and dengue virus (DENV) IgG antibodies with an enzyme-linked immunosorbent assay and confirmed by a plaque reduction neutralization test for DENV, WNV, Zika virus (ZIKV) and Saint Louis encephalitis virus (SLEV). Results :  Among the 910 samples , 2% were positive for specific IgG antibo...

  Abstract The severity of influenza is often driven by an excessive host immune response rather than the virus itself , yet the key molecular drivers within specific immune cells remain poorly understood. While recent single-cell RNA sequencing studies have successfully identified immune populations involved, they have largely not identified the upstream drivers modulating their pro-inflammatory functions . Here we employed an integrated single-cell co-expression network to address this gap. Our analysis identified myeloid dendritic cells (mDCs) as central to pro-inflammatory response during infection. Through a multi-layered key driver analysis, we pinpointed C-type lectin , CLEC4E as a top candidate modulating this pathological inflammatory response . The role of CLEC4E was confirmed in an independent single-cell dataset from influenza-infected patients and further validated in vivo. Pharmacological inhibition of CLEC4E in a murine influenza model significantly reduced disease s...