ETIDIOH - NEW

  ABSTRACT Common cold coronaviruses, such as OC43 and HKU1, typically cause mild respiratory infections in healthy people. However, they can lead to severe illness in high-risk groups , including immunocompromised individuals and older adults. Currently, there is no clinically approved vaccine to prevent infection by common cold coronaviruses. Here, we developed an mRNA vaccine expressing a stabilized spike protein derived from OC43 coronavirus and tested its efficacy in different challenge models in C57BL/6 mice . This novel OC43 vaccine elicited OC43-specific immune responses, as well as cross-reactive immune response against other embecoviruses , including HKU1 and mouse hepatitis virus (MHV-A59). Interestingly, this OC43 vaccine protected mice not only against a lethal OC43 infection but also against a distant embecovirus, MHV-A59. These findings provide insights for the development of common cold coronavirus vaccines, demonstrating their potential to protect against various c...

  Abstract Background :  The purpose of this study was to retrospectively analyse the clinical presentation of RSV, Influenza , and SARS-CoV-2 infections in children across three consecutive seasons (2022/2023; 2023/2024; and 2024/2025).  Methods :  Of the 321 hospitalised patients , 129 ( 36% ) tested positive for RSV , 110 ( 38% ) for Influenza , and 82 ( 26% ) for SARS-CoV-2 . Children were aged ≤ 17 years (median: 15 months). The data were statistically analysed using the χ2 test, multinomial multivariable logistic regression, OR (odds ratio), and 95% CI (confidence interval).  Results :  Significant independent predictors of RSV infection were auscultatory abnormalities (OR: 15.9 [1.49–169]) and hospital admission ≥ 4 days after symptom onset (OR: 32.5 [1.19–907]). Among RSV-positive patients , compared with those aged < 6 months , those aged 7–24 months were more likely to present with higher CRP levels (OR 1.06 [1.003–1.13]), reduced appetite (OR ...

  {Di Riki7 - Opera propria, Pubblico dominio, https://commons.wikimedia.org/w/index.php?curid=6957499 } A farm with Meleagris gallopavo species birds in Vlaanderen Region.  Source: WOAH,  https://wahis.woah.org/#/in-review/6921 ____

Non-poultry birds at a hobbyist's premise in Wallonie Region. Source: WOAH,  https://wahis.woah.org/#/in-review/6908 ____

  {By Norbert Kenntner, Berlin - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=1062838 } A wild Northern Goshawk in Hokkaido Region. Source: WOAH,  https://wahis.woah.org/#/in-review/6909 ____

{ob1-Shiraoi-Town} On 21 October 2025, a Livestock Hygiene Service Centre (LHSC) in Hokkaido Prefecture received a notification from a domestic layer farm regarding an increase in bird mortality. Samples were collected from birds on the farm by LHSC officers and tested positive for influenza A virus using a viral antigen rapid test. On 22 October, the LHSC conducted RT-PCR and rRT-PCR tests and confirmed that the virus is of high pathogenicity . Movement and shipment restriction have been imposed on farms within a radius of 3 km and 10 km of the affected farm, respectively. Stamping-out and relevant control measures, including disinfection, are ongoing. The National Institute of Animal Health (NIAH) is sequencing the virus genome and will identify the subtype. Source: WOAH,  https://wahis.woah.org/#/in-review/6911 ____

  Establishment registered for the direct supply of small quantities of animal products from the farm to the consumer: - 150 pcs Gallus gallus (22 dead) - 26 pcs geese (5 dead) - 21 pcs ducks (no clinical signs) Sudden deaths, haemorrhagies of the inner organs (intestines, spleen, lungs). Depopulation is ongoing. Source: WOAH,  https://wahis.woah.org/#/in-review/6916 ____