ETIDIOH - NEW

  Summary -- What is already known about this topic? -  Influenza-associated encephalopathy (IAE) is a rare, severe neurologic complication of influenza. -- What is added by this report? - During the high-severity 2024–25 influenza season, 109 U.S. pediatric IAE cases were identified; 55% of affected children were previously healthy . Thirty-seven IAE cases were subcategorized as acute necrotizing encephalopathy (ANE), a severe form of IAE characterized by rapid neurologic decline and a poor prognosis . Overall, 74% of IAE patients were admitted to an intensive care unit , and 19% died ; 41% of ANE patients died. Only 16% of vaccine-eligible IAE patients had received the 2024–25 influenza vaccine. -- What are the implications for public health practice? - All children are at risk for severe neurologic complications of influenza . Annual influenza vaccination is recommended for all children aged ≥6 months to prevent influenza and associated complications, potentially including ...

  A poultry farm in Gyeonggi-do Region. Source: WOAH,  https://wahis.woah.org/#/in-review/6805 ___

  {By Sanchezn - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=3019282 } Three wild mute swans in Dolnośląskie Region. Source: WOAH,  https://wahis.woah.org/#/in-review/6815 ____

  Summary Background Cancer is a leading cause of death globally. Accurate cancer burden information is crucial for policy planning , but many countries do not have up-to-date cancer surveillance data. To inform global cancer-control efforts, we used the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 framework to generate and analyse estimates of cancer burden for 47 cancer types or groupings by age, sex, and 204 countries and territories from 1990 to 2023, cancer burden attributable to selected risk factors from 1990 to 2023, and forecasted cancer burden up to 2050. Methods Cancer estimation in GBD 2023 used data from population-based cancer registration systems , vital registration systems, and verbal autopsies. Cancer mortality was estimated using ensemble models , with incidence informed by mortality estimates and mortality-to-incidence ratios (MIRs). Prevalence estimates were generated from modelled survival estimates, then multiplied by disability weig...

  Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has impacted global health. Remdesivir was approved based on clinical trials demonstrating improved outcomes in hospitalized patients. The ReEs-COVID19 study provides real-world evidence on its effectiveness and safety across two periods: Pre-Omicron and Omicron. This retrospective, observational cohort study included 1610 patients hospitalized with COVID-19 , treated with remdesivir during Pre-Omicron (September 2020–February 2021; n = 606) and Omicron (June 2022–March 2023; n = 1004) periods. Primary endpoint: time to discharge; Hepatic/renal function abnormalities were also investigated. In the Omicron period patients were older and had more comorbidities but remdesivir was initiated earlier (median: 2 days from symptom onset) compared to the Pre-Omicron period (8 days). ICU admissions rates and direct COVID-19-related deaths were significantly lower , but overall 30-day mortality was higher during the Omicr...