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Showing posts from September 13, 2025

Shifting tides: increased #severity despite fewer visits for #infant respiratory #infections across two consecutive post-pandemic winters in Northern #Italy

  Abstract This study compares infant (0–24 months) respiratory infection presentations to a Northern Italian paediatric emergency department across two post-pandemic winters ( 2022–2023 vs 2023–2024 ). Despite an approximate 44% reduction in visits in 2023–2024 (N=176 in 2023–2024 vs N=317 in 2022–2023), infants in the 2023–2024 season experienced significantly higher proportions of ventilatory support (51.1% vs 32.8%, p<0.001) and intensive care unit admission (15.9% vs 1.9%, p<0.001) than those presenting in 2022–2023, with a non-significant trend towards higher hospitalisation (88.1% vs 81.7%, p=0.052). Respiratory syncytial virus re-emerged as the dominant pathogen (43.2% vs 27.7%, p<0.001) in 2023–2024, alongside increased human metapneumovirus and influenza A H1N1 . These findings highlight a concerning shift towards increased severity, underscoring the need for ongoing surveillance. Source: BMJ Paediatric Open,  https://bmjpaedsopen.bmj.com/content/9/1/e003695...

History of Mass Transportation: The FS Class E.402 Electric Locomotive

  By Bahnfrend - Own work, CC BY-SA 3.0,  https://commons.wikimedia.org/w/index.php?curid=18053425 Source: Wikipedia,  https://en.wikipedia.org/wiki/FS_Class_E.402 ____

#Coronavirus Disease Research #References (by AMEDEO, September 13 '25)

  Am J Respir Crit Care Med GORDHAN BG, Sewcharran A, Waja Z, Martinson N, et al Oral Rinse as an Alternative Diagnostic Specimen for Detection of Tuberculosis. Am J Respir Crit Care Med. 2025 Sep 12. doi: 10.1164/rccm.202503-0723. PubMed          CRESCIOLI E, Klitgaard TL, Riis JO, Weinreich UM, et al Oxygenation Targets and Long-Term Cognitive and Pulmonary Functions in Hypoxemic Respiratory Failure. Am J Respir Crit Care Med. 2025 Sep 8. doi: 10.1164/rccm.202412-2499. PubMed           Abstract available Clin Infect Dis NADIG N, Bhimraj A, Cawcutt K, Chiotos K, et al 2025 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Treatment and Management of COVID-19: Abatacept. Clin Infect Dis. 2025 Sep 9:ciaf354. doi: 10.1093. PubMed           Abstract available Infect Control Hosp Epidemiol WILLIAMS V, Volpentesta K, Avaness M, Chan C, ...

#Influenza and Other Respiratory Viruses Research #References (by AMEDEO, September 13 '25)

  Antiviral Res ICHIKAWA T, Tamura T, Nao N, Suzuki H, et al Characterization of remdesivir resistance mutations in COVID-19 patients with various immunosuppressive diseases. Antiviral Res. 2025;242:106264. PubMed           Abstract available BI W, Zhu T, Xu Y, Chen Y, et al An engineered chimeric ACE2-HR2 peptide exhibits potent and broad-spectrum activity against SARS-CoV-2 variants. Antiviral Res. 2025;242:106265. PubMed           Abstract available TERATAKE Y, Okamura T, Ishizaka Y SMAD5 phosphorylation by ALK1 is modulated by the interaction of the spike protein of SARS-CoV-2 and angiotensin-converting enzyme 2. Antiviral Res. 2025;242:106261. PubMed           Abstract available YAO G, Shi X, Jiang H, Duan A, et al Design, synthesis, and biological evaluation of novel 6-aminoalkyl- and 7-heteroaryl substituted 7-deazapurine nucleoside analogs against SARS-CoV...