ETIDIOH - NEW

{England} 300k laying hen premises. Samples were taken and were tested positive for HPAI H5N1. Clinical signs were presented prior to testing. Source: WOAH,  https://wahis.woah.org/#/in-review/6907 ____

  Highlights •  Human antibody HB420 cross-reacts with neuraminidases from H3N2 and H5N1 •  HB420 engages the neuraminidase active site via a single Asp residue •  Germline HB420 is N2 specific but gains reactivity to N1 through somatic mutation •  HB420 provides in vivo protection against both H3N2 and H5N1 Summary The ongoing spread of highly pathogenic avian influenza H5N1 clade 2.3.4.4b virus in animals and its occasional spillover to humans have raised concerns about a potential H5N1 pandemic . Although recent studies have shown that pre-existing human antibodies can recognize H5N1 neuraminidase , the molecular basis of how this cross-reactivity develops remains poorly understood. In this study, we used a phage display antibody library derived from 245 healthy donors to isolate an antibody , HB420, that cross-reacts with neuraminidases of human H3N2 and avian H5N1 clade 2.3.4.4b viruses and confers protection in vivo . Cryogenic electron microscopy analysis...

  PURPOSE AND SCOPE   -- With the initiation of the first phase of the ceasefire , humanitarian needs remain dire.  -- In the current situation , it is crucial to scale up humanitarian aid in a coordinated manner while ensuring the start of early recovery and reconstruction.  -- This document summarizes WHO’s key planning assumptions , strategic priorities and selected activities.  -- The activities fall within the scope of the overall 2025 WHO operational response and early recovery plan for the occupied Palestinian territory and the One-UN multi-sectoral Gaza Ceasefire Humanitarian Response Plan Summary 60 days (13 October 2025). ASSUMPTIONS   -- This plan is developed under the following assumptions :   - Continuation of ceasefire and improvement of the law-and-order situation. - Improved access for UN with access/registration issues for INGOs remaining. - Gradual emergence of a clear and functional governance structure.  - Improved flexi...