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Showing posts from October 17, 2025

#Iceland - #Influenza A #H5 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

  {[ Common Raven ] By Accipiter (R. Altenkamp, Berlin) - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=6806927 } ___ Note 16/10/2025 : The case reported in this event was confirmed to be H5 but was negative for N1 and N5. Therefore, it is assumed that a new serotype has been detected in the country. The raven was found sick with a broken wing, emaciated and with diarrhea. It was euthanized. Source: WOAH,  https://wahis.woah.org/#/in-review/6868 ____

#Italy - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Follow up report 1

  {[ Mallard duck ] By This picture was realized by Richard Bartz by using a Canon EF 70-300mm f/4-5.6 IS USM Lens - Own work, CC BY-SA 2.5, https://commons.wikimedia.org/w/index.php?curid=6449086 } {[ Common Teal ] By Shantanu Kuveskar - Own work, CC BY-SA 4.0, https://commons.wikimedia.org/w/index.php?curid=78923110 } ___ A wild mallard in Veneto Region. A wild common teal in Friuli-Venezia Giulia Region. Source: WOAH,  https://wahis.woah.org/#/in-review/6896 ____

Burden of 375 #diseases and injuries, #risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories...

  Summary Background For more than three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has provided a framework to quantify health loss due to diseases, injuries, and associated risk factors . This paper presents GBD 2023 findings on disease and injury burden and risk-attributable health loss, offering a global audit of the state of world health to inform public health priorities. This work captures the evolving landscape of health metrics across age groups, sexes, and locations, while reflecting on the remaining post-COVID-19 challenges to achieving our collective global health ambitions. Methods The GBD 2023 combined analysis estimated years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs) for 375 diseases and injuries , and risk-attributable burden associated with 88 modifiable risk factors. Of the more than 310 000 total data sources used for all GBD 2023 (about 30% of which were new to this est...

#Evolution of #WHO #Influenza #Antiviral #Stockpile: Rapid Access and Use in Low- and Middle-Income Countries for Pandemic Preparedness and Response

  Abstract The SARS outbreak and influenza A(H5N1) infections (2003–2004) prompted WHO to establish a global influenza antiviral stockpile , enabling rapid distribution to 72 countries during the 2009 A(H1N1) pandemic. To improve access in low- and middle-income countries, WHO added antivirals to the WHO Model List of Essential Medicines and included them in the Prequalification Programme . The 2011 Pandemic Influenza Preparedness Framework refined strategies for equitable access and rapid response. Lessons from COVID-19 led to a new WHO-led mechanism—the Interim Medical Countermeasures Network (i-MCM-net)— which supports integrated supply chains, real-time data sharing, research and development, and equitable access. WHO continues to emphasise equity and global solidarity , highlighting the need for accessible, effective, and affordable antivirals alongside vaccines to protect vulnerable populations and mitigate the impact of future pandemics. Source: Journal of Infectious Disease...

Introduction and Update: #Advances in #Influenza #Therapeutics

  Abstract This supplement contains 17 articles addressing various aspects of advances in influenza therapeutics and related strategies (e.g., diagnostics, rapid access strategies , and resistance monitoring ) for preventing and treating seasonal, zoonotic, and pandemic influenza . In addition to briefly introducing each article, we highlight shortcomings in current use, knowledge gaps requiring further study, and therapeutics of interest entering or advancing in clinical development. Source: Journal of Infectious Diseases,  https://academic.oup.com/jid/article/232/Supplement_3/S169/8287899?login=false ____

Use of #Influenza #Antivirals to Prevent #Transmission

  Abstract Influenza antivirals play an important role in the prevention and control of influenza. We reviewed data on the effectiveness of influenza antivirals for reducing influenza transmission . We found that antiviral prophylaxis , whether given pre- or postexposure , has been shown to reduce the risk of symptomatic influenza in a variety of settings and populations . During pandemic responses, antiviral prophylaxis could play an important role, as demonstrated by the use of amantadine in the 1968–1969 influenza A(H3N2) pandemic and oseltamivir during the 2009–2010 influenza A(H1N1)pdm09 pandemic. Antiviral treatment reduces symptom severity, prevents complications, and can reduce onward transmission of infection. However, resistance, accessibility, and timing pose challenges. Future research directions include innovative therapies and combination treatments. Continued research and stewardship are crucial to optimize antiviral impact. Source: Journal of Infectious Diseases,...