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Showing posts from November 5, 2025

Controlled #human #influenza #infection reveals heterogeneous expulsion of infectious virus into #air

  Abstract Influenza virus is transmitted via respiratory expulsions, but detection of infectious virus in such expulsions has been challenging . Here, we describe quantification and genotyping of infectious virus in respiratory particles using a Modular Influenza Sampling Tunnel (MIST). The particles deposit on cell monolayers , enabling culture, quantification, and sequencing of viruses. Concomitantly, water-sensitive paper and fine particle samplers yield respiratory particle counts over a broad size range. Using the MIST, we captured infectious virus from humans experimentally infected with influenza virus on multiple days post-inoculation . The recovered respiratory particles varied in quantity over three orders of magnitude and contained viral genetic variation that was also detected in samples from infected individuals. Expulsion of infectious virus was associated with infectious viral load in saliva and nasopharyngeal swabs and with clinical symptoms . These data reveal the...

#Ireland - High pathogenicity avian #influenza #H5N1 viruses (#poultry) (Inf. with) - Immediate notification

  A sudden increased mortality in a commercial turkey flock. Samples were collected and submitted to the Irish Central Veterinary Research Laboratory for avian influenza testing. On 4th November 2025 highly pathogenic avian influenza sub. H5N1 was confirmed by the national reference laboratory. Source: WOAH,  https://wahis.woah.org/#/in-review/6976 ____

#UK - #Influenza A #H5N1 viruses of high pathogenicity (Inf. with) (non-poultry including wild birds) (2017-) - Immediate notification

  {By Lukasz Lukasik - The uploader on Wikimedia Commons received this from the author/copyright holder., CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=816655 } {Isle of Man} 1 wild bird (common buzzard) was found dead on 27/10/2025. Official samples were taken and tested positive for HPAI H5N1. Source: WOAH,  https://wahis.woah.org/#/in-review/6977 ____

#Kyasanur Forest #disease: an emerging #arboviral #threat

  Summary Kyasanur Forest disease is a neglected tick-borne viral haemorrhagic fever endemic to India's Western Ghats , caused by the Kyasanur Forest disease virus , a flavivirus transmitted by Haemaphysalis spinigera ticks . The virus circulates in a sylvatic cycle among monkeys, rodents, shrews, birds, and ixodid ticks , and is transmitted to humans incidentally via tick bites . Since its discovery in 1957 in Karnataka , Kyasanur Forest disease has spread to other Indian states, driven by deforestation , forest fragmentation , and increased human incursion into wildlife habitats . Clinically, the disease manifests in a biphasic pattern , with haemorrhagic and neurotropic presentations . Although a formalin-inactivated vaccine is available , its efficacy is not promising, and no antivirals have been approved to date. Field reports indicate that mortality in monkeys might serve as an early indicator of forthcoming human outbreaks. The transmission dynamics of Kyasanur Forest diseas...