ETIDIOH - NEW

  Abstract Finland faced an outbreak of highly pathogenic clade 2.3.4.4b A(H5N1) avian influenza in 2023, which spread from wild birds to fur farms . Vaccinations of at-risk individuals began in June 2024 using the MF59-adjuvanted inactivated A(H5N8) vaccine (Seqirus; A/Astrakhan/3212/2020, clade 2.3.4.4b). Here, in an observational study , we assessed vaccine-induced immune responses in occupational at-risk individuals participating in the phase IV trial , including virus-specific antibody (n = 39 individuals) and T-cell (n = 18 individuals) responses. Vaccination elicited functional antibodies against the vaccine virus and two heterologous clade 2.3.4.4b strains associated with outbreaks on Finnish fur farms and dairy cattle in the United States . Among previously unvaccinated individuals, seroprotection rates against the vaccine virus were 83% (95% CI 70–97%) by microneutralization assay (titre ≥20) and 97% (90–100%) by haemagglutination inhibition assay (titre ≥40). In those pr...

  By Anidaat - Own work, CC BY-SA 4.0,  https://commons.wikimedia.org/w/index.php?curid=130774110 Source:  Link:  https://commons.wikimedia.org/wiki/Category:SNCF_Class_BB_67400,_Livr%C3%A9e_Bleue_Diesel ____

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