ETIDIOH - NEW

  Abstract Avian influenza viruses (AIVs) pose a significant zoonotic threat, with the emerging H3N8 subtype raising increasing concern due to sporadic human infections . Current strategies for risk assessment of novel AIVs primarily rely on genetic surveillance and isolated case reports, which provide limited insight into their cross-species transmission potential . However, these approaches may overlook critical phenotypic determinants , such as pathogenicity, transmissibility, and environmental persistence , that directly influence zoonotic risk . This study investigates the evolutionary relationships , receptor-binding properties, replication dynamics, pathogenicity in mice, transmission efficiency in guinea pigs, and environmental persistence of three H3N8 strains isolated from a live poultry market . All three H3N8 strains bound exclusively to α-2,3 sialic acid receptor and achieved 100% transmissibility among guinea pigs through direct contact . Notably, the environment-orig...

  Par Didier Duforest — Travail personnel, CC BY-SA 4.0,  https://commons.wikimedia.org/w/index.php?curid=52411713 Source:  Link:  https://fr.wikipedia.org/wiki/Autorail_Renault#1959_X_4200 ____

  Abstract Finland faced an outbreak of highly pathogenic clade 2.3.4.4b A(H5N1) avian influenza in 2023, which spread from wild birds to fur farms . Vaccinations of at-risk individuals began in June 2024 using the MF59-adjuvanted inactivated A(H5N8) vaccine (Seqirus; A/Astrakhan/3212/2020, clade 2.3.4.4b). Here, in an observational study , we assessed vaccine-induced immune responses in occupational at-risk individuals participating in the phase IV trial , including virus-specific antibody (n = 39 individuals) and T-cell (n = 18 individuals) responses. Vaccination elicited functional antibodies against the vaccine virus and two heterologous clade 2.3.4.4b strains associated with outbreaks on Finnish fur farms and dairy cattle in the United States . Among previously unvaccinated individuals, seroprotection rates against the vaccine virus were 83% (95% CI 70–97%) by microneutralization assay (titre ≥20) and 97% (90–100%) by haemagglutination inhibition assay (titre ≥40). In those pr...

  By Anidaat - Own work, CC BY-SA 4.0,  https://commons.wikimedia.org/w/index.php?curid=130774110 Source:  Link:  https://commons.wikimedia.org/wiki/Category:SNCF_Class_BB_67400,_Livr%C3%A9e_Bleue_Diesel ____

  Am J Respir Crit Care Med SARMA A, Christenson SA, Shoshana BZ, Oliveira AP, et al Acute Respiratory Distress Syndrome Molecular Phenotypes Have Distinct Lower Respiratory Tract Transcriptomes. Am J Respir Crit Care Med. 2025;211:2352-2362. PubMed           Abstract available Ann Intern Med SOUMARE A, Kapfer T, Botrel T, Adda L, et al Systemic Corticosteroids, Mortality, and Infections in Pneumonia and Acute Respiratory Distress Syndrome : A Systematic Review and Meta-analysis. Ann Intern Med. 2025 Dec 2. doi: 10.7326/ANNALS-25-03055. PubMed           Abstract available BMJ LOGAN M FDA claims 10 child deaths caused by covid-19 vaccine, vows to tighten vaccine approvals. BMJ. 2025;391:r2546. PubMed          Graefes Arch Clin Exp Ophthalmol NEO YN, Martinez-Alvarez L, Davagnanam I, Girafa G, et al Treatment of post-vaccination optic neuritis: implications from the glob...

  Antiviral Res XIONG R, Wu Y, Wang Y, Qu Z, et al Rapid generation of a murine RSV infectious model by transducing a conditional knock-in mouse harboring human IGF1 receptor with adenoviral vector. Antiviral Res. 2025;244:106304. PubMed           Abstract available SUTTO-ORTIZ P, Selisko B, Ferron F, Sommadossi JP, et al Mapping the impact of 1'-, 2'- and 4'-nucleotide modifications on the Respiratory Syncytial Virus RNA-dependent RNA polymerase. Antiviral Res. 2025;244:106298. PubMed           Abstract available Biochem Biophys Res Commun MOHAMMED A, Ibrahim NA, Basher NS Innovations and challenges in vaccine development: Lessons from the SARS-CoV-2 pandemic and prospects. Biochem Biophys Res Commun. 2025;792:152947. PubMed           Abstract available J Gen Virol METAXAKI M, Ram R, Perera M, Wills M, et al Robust antibody and T cell responses tracked longitudin...