ETIDIOH - NEW

  Abstract SARS-CoV-2 rapidly adapts to new hosts following cross-species transmission; this is highly relevant as unique within-host variants have emerged following infection of susceptible wild and domestic animal species . Furthermore, SARS-CoV-2 transmission from animals (e.g., white-tailed deer, mink, domestic cats, and others) back to humans has been observed , documenting the potential of animal-derived variants to infect humans. Here, we investigate SARS-CoV-2 evolution and host-specific adaptation during an outbreak in Amur tigers (Panthera tigris altaica), African lions (Panthera leo), and spotted hyenas (Crocuta crocuta) at Denver Zoo in 2021 . SARS-CoV-2 genomes from longitudinal samples from 16 individuals are evaluated for within-host variation and genomic signatures of selection, and we determine that the outbreak was likely initiated by a single spillover of a rare Delta sublineage . Within-host virus populations rapidly expand and diversify, and we detect signature...

  Par Didier Duforest — Travail personnel, CC BY-SA 3.0,  https://commons.wikimedia.org/w/index.php?curid=12918351 Source:  Link:  https://fr.wikipedia.org/wiki/Autorail_Renault# ____

  Highlights •  Infectious SARS-CoV-2 were detected in nasopharynx and on the surface of corpses •  Viral load and symptom-to-discovery time are linked to viral infectivity •  Infectious viruses were not found in the body fluids •  Our findings highlight strict infection control for COVID-19 corpse handling Abstract Objectives The SARS-CoV-2 pandemic has resulted in millions of deaths worldwide . However, the risk of transmission from COVID-19 corpses remain unclear, posing challenges for forensic medicine in establishing effective infection control measures during autopsies . This study aimed to investigate the presence of infectious SARS-CoV-2 in corpses and identify factors affecting viral infectivity. Methods External examinations of 76 corpses with COVID-19 were performed, and nasopharyngeal, perioral, hand swabs, serum, cerebrospinal fluid (CSF), and urine samples were collected. Viral RNA was quantified by using digital PCR, and infectious viruses were as...