Skip to main content

The #OneHealth challenges and opportunities of the #H5N1 #outbreak in dairy #cattle in the #USA

ABSTRACT

The outbreak of H5N1 in dairy cattle in United States revealed challenges in identification and management of a novel disease. The virus showed an exceptional ability to spread between farms and among cows within a farm. The impact of the virus on dairy cattle varied from nonclinical to severe clinical signs and death. Many dairy producers did not report clinical signs in their cows or test for the virus. Cats and peridomestic birds on many affected dairies died from viral exposure. Dairy workers showed signs of conjunctivitis, which was confirmed to be due to H5N1. With the disease affecting multiple species and showing efficient cow-to-cow transmission, the situation only worsened. There was a negative impact on the relationships among dairy producers, dairy workers, poultry producers, and veterinarians, in which professional and personal relationships were severed and some experienced loss of employment. The regulatory response varied by geographic location, and in some states, animal health and human health authorities elevated producer fears of consequences of reporting. Authorities did quickly confirm that pasteurization inactivated the virus in dairy products and showed that it was very rarely detected in beef from affected cows. In this review, we will describe the relationships among the dairy industry and animal and human health and why the H5N1 outbreak requires a One Health perspective of all stakeholders in order to address it effectively.

Source: Journal of Dairy Science, https://www.journalofdairyscience.org/article/S0022-0302(25)00281-4/fulltext

____

Comments

Popular posts from this blog

#Neuroinvasive #Oropouche virus in a patient with #HIV from extra-Amazonian #Brazil

{Excerpt} A novel reassortant Oropouche virus (OROV) lineage (with medium [M], large [L], and small [S] RNA segments : M1L2S2) has driven Brazil's largest and most geographically widespread OROV epidemic , expanding beyond the endemic Amazon basin to establish local transmission across multiple Brazilian states and other previously unaffected Latin American countries . The rapid spread of this lineage underscores its evolutionary potential and reinforces its significance as a public health threat .1 Similar to chikungunya and Zika viruses, expanding arboviruses can exhibit unexpected clinical and epidemiological shifts , including vertical transmissions , neuroinvasive effects, and potentially fatal outcomes.2–4 Although OROV typically causes self-limited febrile illness, accumulating clinical and experimental evidence suggests neurotropic potential .5 This Correspondence describes the first confirmed case of neuroinvasive OROV infection caused by the emergent M1L2S2 lineage in ext...

No evidence of immune #exhaustion after repeated #SARS-CoV-2 #vaccination in vulnerable and healthy populations

Abstract Frequent SARS-CoV-2 vaccination in vulnerable populations has raised concerns that this may contribute to T cell exhaustion , which could negatively affect the quality of immune protection. Herein, we examined the impact of repeated SARS-CoV-2 vaccination on T cell phenotypic and functional exhaustion in frail older adults in long-term care (n = 23), individuals on immunosuppressive drugs (n = 10), and healthy adults (n = 43), in Canada . Spike-specific CD4+ and CD8+ T cell levels did not decline in any cohort following repeated SARS-CoV-2 vaccination, nor did the expression of exhaustion markers on spike-specific or total T cells increase. T cell production of multiple cytokines (i.e. polyfunctionality) in response to the spike protein of SARS-CoV-2 did not decline in any cohort following repeated vaccination. None of the cohorts displayed elevated levels of terminally differentiated T cells following multiple SARS-CoV-2 vaccinations. Thus, repeated SARS-CoV-2 vaccination was...

Chimeric #hemagglutinin and #M2 #mRNA #vaccine for broad #influenza subtype protection

Abstract Since multiple and unpredicted influenza viruses cause seasonal epidemics and even high-risk pandemics , developing a universal influenza vaccine is essential to provide broad protection against various influenza subtypes. Combined with the mRNA lipid nanoparticle-encapsulated (mRNA-LNP) vaccine platform and chimeric immunogen strategy , we developed a novel cocktail mRNA vaccine encoding chimeric HAs (cH5/1-BV, cH7/3) and intact M2 (termed Fluaxe), which confers broad protection against major circulating IAVs and IBVs , as well as highly pathogenic avian influenza . Two-dose intramuscular immunization of Fluaxe in mice elicited cross-reactive neutralizing antibodies , T cell responses, and long-lived immunity, resulting in robust protection against multiple lethal influenza virus infections and severe acute lung injuries . In particular, intramuscular administration stimulated systemic immunity together with a prominent lung tropism of memory cells . Moreover, Fluaxe immuniza...