ETIDIOH - NEW

  Context and significance The avian influenza A virus subtype H10N3 is a possible candidate for causing a fatal flu and may present a serious public health threat . Research increasingly shows that the avian influenza virus H10N3 can be transmitted from birds to humans , causing severe viral pneumonia and potentially leading to acute respiratory distress syndrome and respiratory failure . Researchers at the Fourth People’s Hospital of Nanning (China) provide evidence supporting the cross-species transmission of the avian influenza virus H10N3 to humans, which can give rise to severe pneumonia. The authors report that a female patient with avian influenza virus H10N3 infection, who was suffering from severe pneumonia , respiratory failure, pneumothorax , and numbness and dysesthesia in her feet , recovered after receiving appropriate therapy and was discharged from the hospital. Highlights •  A young woman contracted the avian influenza virus H10N3 •  Secondary infections...

  Von JoachimKohlerBremen - Eigenes Werk, CC BY-SA 4.0,  https://commons.wikimedia.org/w/index.php?curid=50664108 Source: Wikipedia,  https://de.wikipedia.org/wiki/Schweizerische_Lokomotiv-_und_Maschinenfabrik ____

  J Infect GRANVIK C, Persson IL, Barros GWF, Ahlm C, et al Long-term Physical Capacity Following COVID-19: A Prospective, Three-Year Study. J Infect. 2025 Sep 12:106614. doi: 10.1016/j.jinf.2025.106614. PubMed           Abstract available J Med Virol BADAR N, Salman M, Ahad A, Mirza HA, et al Tracking SARS-CoV-2 Lineages in Pakistan's 2025 COVID-19 Resurgence: Insights From Genomic Surveillance. J Med Virol. 2025;97:e70607. PubMed          LIU S, Shao C, Ding Y, Wang Y, et al Ubiquitination: A Double-Edged Mechanism in Coronavirus Infections. J Med Virol. 2025;97:e70589. PubMed           Abstract available J Virol CHIOK KL, Jenik K, Fenton M, Falzarano D, et al MERS-CoV and SARS-CoV-2 infection in diverse human lung organoid-derived cultures. J Virol. 2025 Sep 18:e0109825. doi: 10.1128/jvi.01098. PubMed           Abstract availa...

  Ann Intern Med FELDMAN CH, Santacroce L, Bassett IV, Thaweethai T, et al Social Determinants of Health and Risk for Long COVID in the U.S. RECOVER-Adult Cohort. Ann Intern Med. 2025 Jul 29. doi: 10.7326/ANNALS-24-01971. PubMed           Abstract available Arch Virol PUENPA J, Dara S, Vichaiwattana P, Aeemjinda R, et al Seasonal dynamics and genetic diversity of human rhinoviruses in patients with acute respiratory infection in Bangkok in 2024. Arch Virol. 2025;170:208. PubMed           Abstract available J Gen Virol DI GENOVA C, Warren CJ, Johnson S, Riccio S, et al Pigeons exhibit low susceptibility and poor transmission capacity for H5N1 clade 2.3.4.4b high pathogenicity avian influenza virus. J Gen Virol. 2025;106. PubMed           Abstract available PHAN N, Zaytseva Y, Lin CC, Mishra M, et al PUM2 binds SARS-CoV-2 RNA and PUM1 mildly reduces viral RNA levels...

  {Summary} Overall risk and confidence Overall risk -- National: High  -- Regional: Moderate    -- Global: Low    Confidence in available information  -- National: Moderate -- Regional: Moderate -- Global: Moderate Risk statement On 1 September 2025, WHO received an alert from the Ministry of Health of the Democratic Republic of the Congo (DRC) regarding suspected cases of Ebola virus disease (EVD) in the Bulape Health Zone , Kasai Province , DRC.  The first currently known suspected EVD case was admitted to the Bulape General Reference Hospital on 20 August 2025 and reported to have died five days later (25 August 2025). This is a 34-year-old female patient with a 34-week gestational age who presented with fever, bloody diarrhoea, followed by anal, oral, and nasal haemorrhage, vomiting , and asthenia .  She reportedly died on 25 August 2025, with a clinical picture of multiple organ failure.  Two of the contacts of this first case (a m...

  Highlights •  Most vector-borne viruses like alphaviruses are not included in routine diagnostics •  Lack of testing results in misdiagnoses and underdetection •  A new multiplexed real-time PCR assay detects all human pathogenic alphaviruses •  The new multiplex assay is more sensitive than available tests and highly specific •  The multiplex test can be applied broadly for diagnostics and molecular surveillance Abstract Background Knowledge of epidemiology, pathogenesis, and public health burden is scarce for many arthropod-borne viruses (arboviruses). Insufficient knowledge is partly due to lack of exhaustive laboratory diagnostics due to resource limitations . Among arboviruses , arthritogenic and encephalitogenic alphaviruses are globally widespread, can cause severe disease, and can co-occur regionally. Objectives We developed and validated a multiplexed real-time reverse transcription-PCR assay for the detection of all alphaviruses commonly causing...

  Abstract Background Ebola virus disease (EVD) is a severe and often fatal illness with high transmission potential and recurring outbreaks . Traditional compartmental models often neglect biologically important delays , such as the latent period before an infected individual becomes infectious, limiting their ability to capture real-world epidemic patterns. Including such delays can provide a more accurate understanding of outbreak persistence and control strategies. Methods In this study, we develop and analyze a novel deterministic SIRR model that captures the complex transmission dynamics of Ebola by explicitly combining nonlinear incidence rates with a delay differential equation framework . Unlike traditional models, this approach integrates a biologically motivated delay to represent the latent period before infectiousness, providing a more realistic depiction of disease spread. The basic reproduction number (R0) is derived using the next-generation matrix, and local stabil...

  {Summary} Time Period: September 07, 2025 - September 13, 2025 -- H5 Detection :  3 sites ( 0.7% ) -- No Detection :  401 sites ( 99.3% ) -- No samples in last week :  57 sites (...) Source: US Centers for Disease Control and Prevention,  https://www.cdc.gov/nwss/rv/wwd-h5.html ____

  ABSTRACT H10 subtype avian influenza viruses primarily circulate among wild waterfowl but can occasionally infect mammals , including humans , and recent sporadic human cases have raised significant public health concerns . In this study, we sequenced and analysed 59 H10 subtype viruses isolated from wild birds in Taiwan . Results showed that all isolates were genetically distinct from human and other mammalian H10 subtype isolates. Taiwanese isolates exhibited high genetic diversity and could be categorized into 34 distinct genotypes , with each genotype circulating only in a single migratory season and not recurring during subsequent seasons. Additional analyses revealed that certain gene pools frequently circulate in the Pacific Rim , with evidence of North American lineage genes establishing long-term populations in Eurasia and vice versa. Although no characteristics indicative of mammalian adaptation was found in the Taiwanese isolates, temporal changes in the haemagglutinin...

  {Summary} -- During current epidemiological week ( 11– 17 September 2025),  65 new confirmed human cases of infection with West Nile Virus have been reported.  -- The total number of confirmed cases , since the beginning of the epidemic season, has thus risen to 647 (it was 582 last week), of these:  - 300 were West Nile Neuroinvasive Disease (WNND): 15 in Piedmont, 39 Lombardy, 24 Veneto, 2 Friuli-Venezia Giulia, 1 Liguria, 23 Emilia-Romagna, 5 Tuscany, 83 Latium, 2 Molise, 77 Campania, 2 Apulia, 2 Basilicata, 5 Calabria, 1 Sicily, 19 Sardinia,  - 54 were asymptomatic cases detected among blood donors ,  - 284 were West Nile Fever cases (one imported from Kenya),  - 3 asymptomatic cases and  - 6 unspecified casese.  -- Among confirmed cases, there were 47 death cases : 7 in Piedmont, 5 Lombardy, 1 Emilia-Romagna, 16 Latium, 15 Campania, 2 Calabria, 1 Sardinia.  - The Case-Fatality Rate in WNND cases was 15.8% (it was 20% in 2018 and...