ETIDIOH - NEW

  Significance The high-resolution cryo-EM structure indicates that the human antibody 6Y13 binds strongly to a conserved pan-H7 epitope on the hemagglutinin head , distinct from the receptor-binding site and lateral patch. However, 6Y13 can broadly neutralize H7 viruses , fully protect H7N9 -infected mice, and potently block receptor binding through mechanisms, independent of Fc-mediated steric hindrance. Abstract Zoonotic H7N9 avian influenza virus infection remains a global concern because of its pandemic potential . Therefore, developing effective antibodies and vaccines against H7N9 is vital for preventing and controlling major outbreaks . Here, we isolated a human VH3-30 gene-encoded antibody , designated 6Y13 , from a survivor of H7N9 infection . This antibody recognized the hemagglutinins (HAs) of the representative H7 subtype zoonotic viruses spanning two decades of antigenic evolution and potently neutralized epidemic H7N9 viruses in vitro. Moreover, 6Y13 conferred comple...

  {By Diliff - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=1385555 } Following the detection of HPAI H5N1 in a greylag goose found dead near the lake Biel on 4 November 2025, an infected area of 3 km around the three lakes in vicinity of the site of detection has been put in place. Within this area, measures of increased disease awareness, biosecurity and notification obligations have to be followed by poultry owners. A wild Greylag Goose found dead in Bern Region. Source: WOAH,  https://wahis.woah.org/#/in-review/6985 ____

  {England} Mixed commercial premises with 32.7k ducks and 11.6k broilers. Samples taken were positive for HPAI H5N1. Birds presented clinical signs of AI prior to testing. Source: WOAH,  https://wahis.woah.org/#/in-review/6987 ____

  Abstract Samples collected from two avian influenza outbreaks in Bagmati Province in central Nepal between January and March 2023 were positive for H5N1 . Full genomes were generated for both viruses, which revealed that one of the viruses was very similar to clade 2.3.4.4b H5N1 identified in Bangladesh in 2021/2022. The second virus was a reassortant H5N1 virus consisting of four genes (HA, NA, NP, and M) originating from a clade 2.3.2.1a H5N1 and the remaining four genes (NS, PB1, PB2, and PA) originating from a 2.3.4.4b H5N1 . Notably, this second virus had a high identity with 2.3.2.1a clade viruses identified in humans and cats in India in 2024–2025. These are the first full genome sequences of H5N1 avian influenza viruses from Nepal and given the recent human infections by 2.3.2.1a H5N1 viruses in the region, these data will be of interest to both public health and veterinary authorities. Source: Viruses,  https://www.mdpi.com/1999-4915/17/11/1481 ____

  Abstract Mucosal influenza vaccines may provide improved protection against infection and transmission , but their development is hindered by absence of immune correlates of protection . Here, we report a randomized, controlled phase I trial of a recombinant influenza A/H5 (A/Indonesia/05/2005, clade 2.1) hemagglutinin vaccine formulated with a nanoemulsion adjuvant (W805EC). The vaccine is administered intranasally in two doses 28 days apart at three antigen levels. Controls receive unadjuvanted H5 or placebo. Six months later, participants receive an intramuscular boost with unadjuvanted inactivated A/H5N1 (A/Vietnam/1203/2004, clade 1) vaccine. Primary outcomes are solicited and unsolicited adverse events (AEs), laboratory safety abnormalities, medically-attended AEs, potential immune-mediated conditions, new-onset chronic conditions, and serious AEs. All vaccines are well tolerated. After the intranasal series, hemagglutination inhibition and microneutralization responses are...

  Situation at a glance Between 20 September and 30 October 2025, a total of 404 confirmed human cases of Rift Valley fever (RVF), including 42 deaths , were reported by national health authorities in two West African countries : Mauritania and Senegal .  RVF is a zoonotic disease , which mainly affects animals, but can also infect humans.  The majority of human infections result from contact with the blood or organs of infected animals, but human infections have also resulted from the bites of infected mosquitoes .  To date, no human-to-human transmission of RVF has been documented.  While RVF often leads to severe illness in animals, its impact in humans varies, ranging from mild flu-like symptoms to severe hemorrhagic fever that can be fatal .  RVF is endemic in both countries, where recurrent outbreaks have been previously reported in both livestock and humans.  The risk of further spread remains high , especially with environmental conditions favo...

  Abstract Background No vaccine is currently available for Lassa fever, a viral hemorrhagic disease that is estimated to cause thousands of deaths each year in western Africa . A replication-competent recombinant vesicular stomatitis virus–vectored vaccine encoding a Lassa virus (LASV) glycoprotein complex, rVSVΔG-LASV-GPC, has been developed, but data on its safety and immunogenicity are limited. Methods In this phase 1, double-blind trial conducted in the United States and Liberia, we randomly assigned healthy adults (18 to 50 years of age) to receive rVSVΔG-LASV-GPC or placebo intramuscularly . Participants received a single vaccine dose of 2×104 plaque-forming units (PFU), 2×105 PFU, 2×106 PFU, or 2×107 PFU or placebo or received two vaccine doses of 2×107 PFU or placebo, within a window of 6 to 20 weeks. The side-effect profile was assessed according to the incidence of solicited and unsolicited adverse events (primary end point). Because Lassa fever can cause sensorineural h...

  Abstract Influenza virus is transmitted via respiratory expulsions, but detection of infectious virus in such expulsions has been challenging . Here, we describe quantification and genotyping of infectious virus in respiratory particles using a Modular Influenza Sampling Tunnel (MIST). The particles deposit on cell monolayers , enabling culture, quantification, and sequencing of viruses. Concomitantly, water-sensitive paper and fine particle samplers yield respiratory particle counts over a broad size range. Using the MIST, we captured infectious virus from humans experimentally infected with influenza virus on multiple days post-inoculation . The recovered respiratory particles varied in quantity over three orders of magnitude and contained viral genetic variation that was also detected in samples from infected individuals. Expulsion of infectious virus was associated with infectious viral load in saliva and nasopharyngeal swabs and with clinical symptoms . These data reveal the...

  A sudden increased mortality in a commercial turkey flock. Samples were collected and submitted to the Irish Central Veterinary Research Laboratory for avian influenza testing. On 4th November 2025 highly pathogenic avian influenza sub. H5N1 was confirmed by the national reference laboratory. Source: WOAH,  https://wahis.woah.org/#/in-review/6976 ____

  {By Lukasz Lukasik - The uploader on Wikimedia Commons received this from the author/copyright holder., CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=816655 } {Isle of Man} 1 wild bird (common buzzard) was found dead on 27/10/2025. Official samples were taken and tested positive for HPAI H5N1. Source: WOAH,  https://wahis.woah.org/#/in-review/6977 ____

  Summary Kyasanur Forest disease is a neglected tick-borne viral haemorrhagic fever endemic to India's Western Ghats , caused by the Kyasanur Forest disease virus , a flavivirus transmitted by Haemaphysalis spinigera ticks . The virus circulates in a sylvatic cycle among monkeys, rodents, shrews, birds, and ixodid ticks , and is transmitted to humans incidentally via tick bites . Since its discovery in 1957 in Karnataka , Kyasanur Forest disease has spread to other Indian states, driven by deforestation , forest fragmentation , and increased human incursion into wildlife habitats . Clinically, the disease manifests in a biphasic pattern , with haemorrhagic and neurotropic presentations . Although a formalin-inactivated vaccine is available , its efficacy is not promising, and no antivirals have been approved to date. Field reports indicate that mortality in monkeys might serve as an early indicator of forthcoming human outbreaks. The transmission dynamics of Kyasanur Forest diseas...

  ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of coronavirus disease 2019 (COVID-19), is characterized by its high contagiousness. The COVID-19 pandemic has exerted profound impacts on human society . The persistent circulation of SARS-CoV-2 in human populations continues to pose re-exposure risks for both vaccinated individuals and those with prior natural infection. Against this epidemiological background, there is an urgent need to characterize the transmission dynamics of SARS-CoV-2 in the context of pre-existing immunity . Using a ferret infection model , this study systematically addresses critical scientific questions , including viral transmission efficiency , temporal patterns of transmissibility , and the ability of pre-existing immunity to mitigate reinfection and viral shedding. The findings provide robust experimental evidence for elucidating the transmission mechanisms of SARS-CoV-2 and offer scientific insights to info...

  The last outbreak of highly pathogenic avian influenza in poultry in Lubuskie region was confirmed on 11/03/2025. 02/05/2025 is the date of confirmation of the last outbreak in Poland in the spring of 2025. A turkeys slaughterhouse operation in Lubuskie Region. Source: WOAH,  https://wahis.woah.org/#/in-review/6972 ____

  Abstract Influenza is a global health concern, causing over 300,000 deaths worldwide annually . Current vaccines and natural infection mainly elicit antibodies against the variable head domain of the hemagglutinin (HA) glycoprotein. While these antibodies are highly neutralizing, the head domain constantly mutates due to selective pressure , causing the immune response to be strain-specific. Targeting the conserved HA stalk domain , however, has been shown to be a promising approach for a broadly protective vaccine . We previously demonstrated that presenting HA in an inverted orientation on virus-like particles (VLPs) significantly enhanced the induction of stalk-directed, cross-reactive antibodies compared to HA presented in a regular orientation. Here, we evaluated the protective efficacy of the inverted HA vaccine (VLP-HAinv) in mice against homologous, heterologous, and heterosubtypic influenza A virus challenges . VLP-HAinv vaccination in mice provided complete protection a...

  Abstract Emerging infectious diseases can have catastrophic impacts on wildlife populations , yet identifying individuals that survived exposure, especially when external symptoms are absent, remains challenging. Since 2021, a virulent strain of highly pathogenic avian influenza virus (HPAIV H5N1 clade 2.3.4.4b) has caused unprecedented mortality in wild birds across continents . Northern Gannets (Morus bassanus) are among the species that suffered significant population declines in Europe and North America . At North America's largest gannet colony ( Bonaventure Island ) dramatic mortality and reproductive failure occurred in 2022. Following this event, researchers noted a subset of gannets displaying irregular iris pigmentation , raising the possibility that this visible change may indicate a lasting effect of infection. Here, we build on earlier observations linking irregular iris pigmentation to HPAIV exposure in gannets using anti-nucleoprotein (NP) and anti-hemagglutinin (H...

  Abstract Molnupiravir is an antiviral medicine that induces lethal copying errors during SARS-CoV-2 RNA replication . Molnupiravir reduced hospitalization in one pivotal trial by 50% and had variable effects on reducing viral RNA levels in three separate trials. We used mathematical models to simulate these trials and closely recapitulated their virologic outcomes . Model simulations suggested lower antiviral potency against pre-Omicron SARS-CoV-2 variants than against Omicron . We estimated that in vitro assays underestimated in vivo potency by 6- to 7-fold against Omicron variants. Our model suggested that because polymerase chain reaction detects molnupiravir mutated variants, the true reduction in non-mutated viral RNA was underestimated by approximately 0.4 log10 in the two trials conducted while Omicron variants dominated. Viral area under the curve estimates differed significantly between non-mutated and mutated viral RNA. Our results reinforce past work suggesting that in...

  A laying hens farm in Sachsen-Anhalt Region. Source: WOAH,  https://wahis.woah.org/#/in-review/6966 ____

  {Di Sanchezn - Opera propria, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=3019282 } Confirmation of HPAI - H5N1 case, at Cygnus olor Port Contanta Dana 55 in the Constanta county. Source: WOAH,  https://wahis.woah.org/#/in-review/6968 ____

  Abstract The H5N1 high pathogenicity avian influenza virus (HPAIV) of clade 2.3.4.4b, which spreads globally via wild birds , has become a major public health concern because it can infect a variety of mammals , including humans . In 2024, infection of dairy cattle with H5N1 HPAIV clade 2.3.4.4b was confirmed in the United States , and subsequent human cases were reported. Although these viruses are highly pathogenic in animal models , human infections have generally been mild , revealing a striking discrepancy . Here, we characterized the cattle-derived human H5N1 isolate A/Texas/37/2024 (TX37-H5N1) using three-dimensional human respiratory organoids derived from induced pluripotent stem (iPS) cells. Despite efficient replication , TX37-H5N1 induced minimal interferon and inflammatory cytokine responses . Bulk and single-cell RNA sequencing revealed reduced STAT1-mediated transcriptional activity in TX37-H5N1-infected organoids compared to the historic H5N1 human isolate A/Vietn...

  By Tulip Hysteria / Go to albums - https://www.flickr.com/photos/36417567@N03/32380012237/ , CC BY 2.5,  https://commons.wikimedia.org/w/index.php?curid=111521078 Source: Wikipedia,  https://en.wikipedia.org/wiki/Henry_Fuseli ____