ETIDIOH - NEW

  Par Auteur inconnu — Ligne de Sens à Nogent sur Seine in Les Forums de Passions Métrique et Etroite, Beitrag aus dem Jahre 2013. Siehe auch Renault Typ NF im Modellbau-Wiki., Domaine public,  https://commons.wikimedia.org/w/index.php?curid=70650101 Source: Wikipedia,  https://fr.wikipedia.org/wiki/Autorail_Renault ____

  Summary Background Given the continued global circulation of monkeypox virus (MPXV), we aimed to assess the long-term clinical consequences of MPXV infection and the continued presence of the virus in saliva, semen, and the anorectum . We also aimed to compare long-term antibody dynamics after MPXV infection with modified vaccinia Ankara–Bavarian Nordic (MVA-BN) vaccination. Methods In this mixed retrospective and prospective cohort study, adults with acute MPXV infection at the Institute of Tropical Medicine (Antwerp, Belgium) were enrolled in a clinical registry (MPX-COHORT) from May 13, 2022, with follow-up at 1 month after infection. On Oct 3, 2022, we initiated a long-term follow-up study (POQS-FU-PLUS) to extend follow-up of people with mpox and to establish a parallel cohort of adults who received MVA-BN vaccination between Aug 3, 2022, and Jan 4, 2023. Participants were eligible for the second cohort if they received two doses of MVA-BN, unless they had previous smallpox ...

  Abstract Bats are associated with some of the most significant and virulent emerging zoonoses globally , yet research and surveillance of bat pathogens remains limited across parts of the world. We surveyed the prevalence and genetic diversity of coronaviruses from bats in Taita Hills, southeastern Kenya , as part of ongoing surveillance efforts in this remote part of eastern Africa. We collected fecal and intestinal samples in May 2018 and March 2019 from 16 bat species . We detected one genus of coronavirus (alphacoronavirus), with an overall RNA prevalence of 6.5% (30/463). The prevalence of coronavirus RNA was 3.8% (9/235) and 11.6% (21/181) for the two most captured free-tailed bat species, Mops condylurus and M. pumilus respectively, with no detections from other bat species (0/90). Phylogenetic analyses based on the partial RNA-dependent RNA polymerase gene and whole genome sequences revealed that the sequences clustered together and were closely related to alphacoronaviru...

  By Matthias-Tf - Own work, CC BY 4.0,  https://commons.wikimedia.org/w/index.php?curid=161756539 Source: Wikipedia,  https://commons.wikimedia.org/wiki/Category:Brissonneau_et_Lotz_locomotives ____

  Acad Emerg Med OHLE R, Roy D, Baraku E, Patel K, et al A Prospective Multi-Center Implementation Study to Improve the Diagnosis and Treatment of Benign Paroxysmal Positional Vertigo. Acad Emerg Med. 2025 Nov 3. doi: 10.1111/acem.70177. PubMed           Abstract available Am J Obstet Gynecol YE Y, Mahati S, Aihemaiti W, Lu G, et al A postpartum-adapted algorithm for safe management of suspected pulmonary embolism: a retrospective cohort study. Am J Obstet Gynecol. 2025 Nov 1:S0002-9378(25)00813. PubMed           Abstract available Antiviral Res DENG X, Zou J, Liang Z, Ren P, et al A Dual-Reporter HCoV-OC43 for Coronavirus Biology and Countermeasure Development. Antiviral Res. 2025 Nov 3:106306. doi: 10.1016/j.antiviral.2025.106306. PubMed           Abstract available BMJ WISE J Covid-19: Major study compares myocarditis risk in children after vaccination or infec...

  Antimicrob Agents Chemother YAO B-F, Yang Y, Xu S-S, Tang B-H, et al Model-informed drug development in public health emergency of international concern: accelerating marketing authorization of simnotrelvir. Antimicrob Agents Chemother. 2025 Sep 18:e0061425. doi: 10.1128/aac.00614. PubMed           Abstract available LODISE TP, Min J, Nathanson BH, Yucel E, et al Comparison of early treatment with ceftolozane/tazobactam versus polymyxin-based therapy of pneumonia due to MDR Pseudomonas aeruginosa (PUMA). Antimicrob Agents Chemother. 2025;69:e0056925. PubMed           Abstract available DE LA PORTE DES VAUX C, Veyrenche N, Silva KD, Chavarot N, et al Immunocompromised patients with persistent SARS-CoV-2 viral shedding >/=8 weeks, clinical outcomes, and virological dynamics: a retrospective multicenter cohort study, 2020-2024. Antimicrob Agents Chemother. 2025 Sep 26:e0065825. doi: 10.1128/aac.00658....

  {By Kandukuru Nagarjun from Bangalore, India - Peacock on tree, CC BY 2.0, https://commons.wikimedia.org/w/index.php?curid=119724930 } Captive Indian Peafowl birds in Haskovo Region. Source: WOAH,  https://wahis.woah.org/#/in-review/6999 ____

  {Excerpt} On Sept 4, 2025, the DR Congo Government and Ministry of Health announced a new Ebola virus disease outbreak in the Bulape health zone (Kasai province), marking the end of over 15 years without any reported cases of Ebola virus disease in this region . As of Sept 14, 2025, there were 35 confirmed Ebola virus disease cases and 16 deaths , representing a case fatality rate of 45·7%.1,2 This unexpected resurgence in a region with insufficient preparedness capacity raises serious concerns about potential regional spread, including towards neighbouring Angola. At the same time, DR Congo is experiencing one of the most severe cholera outbreaks of the past decade , with a total of 48 139 cases and 1443 deaths reported between Jan 1 and Aug 24, 2025, resulting in a case fatality rate of 3%.3 By epidemiological week 33, high case fatality rates were reported in the provinces of Kwilu (76 cases, 26 deaths; 44%), Sankuru (42 cases, 6 deaths; 14%), and Equateur (224 cases, 19 death...

  Abstract The current panzootic of high pathogenicity avian influenza (HPAI) H5N1 has been catastrophic for wildlife , and following a significant sweep, clade 2.3.4.4b is found in every region aside from Oceania . Herein, we report the results of our third year of targeted surveillance of incoming migratory seabirds and shorebirds into Australia . We did not find evidence of HPAI H5N1 in any of the birds tested , and there were no reports of HPAI H5N1 in wildlife tested through other surveillance schemes in 2024. Unlike previous years, we detected a diversity of low pathogenicity avian influenza (LPAI) viruses in shorebirds. Through phylogenetic analysis we revealed that the H3N7 and H4N7 viruses recovered from Red-necked Stints were complex mosaic viruses, comprising segments of Eurasian, Australian shorebird, and Australian waterfowl segments . A H1N7 virus detected comprised a wholly Eurasian introduction , confirming this route for avian influenza viruses into Australian ecos...

  Significance The high-resolution cryo-EM structure indicates that the human antibody 6Y13 binds strongly to a conserved pan-H7 epitope on the hemagglutinin head , distinct from the receptor-binding site and lateral patch. However, 6Y13 can broadly neutralize H7 viruses , fully protect H7N9 -infected mice, and potently block receptor binding through mechanisms, independent of Fc-mediated steric hindrance. Abstract Zoonotic H7N9 avian influenza virus infection remains a global concern because of its pandemic potential . Therefore, developing effective antibodies and vaccines against H7N9 is vital for preventing and controlling major outbreaks . Here, we isolated a human VH3-30 gene-encoded antibody , designated 6Y13 , from a survivor of H7N9 infection . This antibody recognized the hemagglutinins (HAs) of the representative H7 subtype zoonotic viruses spanning two decades of antigenic evolution and potently neutralized epidemic H7N9 viruses in vitro. Moreover, 6Y13 conferred comple...

  {By Diliff - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=1385555 } Following the detection of HPAI H5N1 in a greylag goose found dead near the lake Biel on 4 November 2025, an infected area of 3 km around the three lakes in vicinity of the site of detection has been put in place. Within this area, measures of increased disease awareness, biosecurity and notification obligations have to be followed by poultry owners. A wild Greylag Goose found dead in Bern Region. Source: WOAH,  https://wahis.woah.org/#/in-review/6985 ____

  {England} Mixed commercial premises with 32.7k ducks and 11.6k broilers. Samples taken were positive for HPAI H5N1. Birds presented clinical signs of AI prior to testing. Source: WOAH,  https://wahis.woah.org/#/in-review/6987 ____

  Abstract Samples collected from two avian influenza outbreaks in Bagmati Province in central Nepal between January and March 2023 were positive for H5N1 . Full genomes were generated for both viruses, which revealed that one of the viruses was very similar to clade 2.3.4.4b H5N1 identified in Bangladesh in 2021/2022. The second virus was a reassortant H5N1 virus consisting of four genes (HA, NA, NP, and M) originating from a clade 2.3.2.1a H5N1 and the remaining four genes (NS, PB1, PB2, and PA) originating from a 2.3.4.4b H5N1 . Notably, this second virus had a high identity with 2.3.2.1a clade viruses identified in humans and cats in India in 2024–2025. These are the first full genome sequences of H5N1 avian influenza viruses from Nepal and given the recent human infections by 2.3.2.1a H5N1 viruses in the region, these data will be of interest to both public health and veterinary authorities. Source: Viruses,  https://www.mdpi.com/1999-4915/17/11/1481 ____

  Abstract Mucosal influenza vaccines may provide improved protection against infection and transmission , but their development is hindered by absence of immune correlates of protection . Here, we report a randomized, controlled phase I trial of a recombinant influenza A/H5 (A/Indonesia/05/2005, clade 2.1) hemagglutinin vaccine formulated with a nanoemulsion adjuvant (W805EC). The vaccine is administered intranasally in two doses 28 days apart at three antigen levels. Controls receive unadjuvanted H5 or placebo. Six months later, participants receive an intramuscular boost with unadjuvanted inactivated A/H5N1 (A/Vietnam/1203/2004, clade 1) vaccine. Primary outcomes are solicited and unsolicited adverse events (AEs), laboratory safety abnormalities, medically-attended AEs, potential immune-mediated conditions, new-onset chronic conditions, and serious AEs. All vaccines are well tolerated. After the intranasal series, hemagglutination inhibition and microneutralization responses are...

  Situation at a glance Between 20 September and 30 October 2025, a total of 404 confirmed human cases of Rift Valley fever (RVF), including 42 deaths , were reported by national health authorities in two West African countries : Mauritania and Senegal .  RVF is a zoonotic disease , which mainly affects animals, but can also infect humans.  The majority of human infections result from contact with the blood or organs of infected animals, but human infections have also resulted from the bites of infected mosquitoes .  To date, no human-to-human transmission of RVF has been documented.  While RVF often leads to severe illness in animals, its impact in humans varies, ranging from mild flu-like symptoms to severe hemorrhagic fever that can be fatal .  RVF is endemic in both countries, where recurrent outbreaks have been previously reported in both livestock and humans.  The risk of further spread remains high , especially with environmental conditions favo...

  Abstract Background No vaccine is currently available for Lassa fever, a viral hemorrhagic disease that is estimated to cause thousands of deaths each year in western Africa . A replication-competent recombinant vesicular stomatitis virus–vectored vaccine encoding a Lassa virus (LASV) glycoprotein complex, rVSVΔG-LASV-GPC, has been developed, but data on its safety and immunogenicity are limited. Methods In this phase 1, double-blind trial conducted in the United States and Liberia, we randomly assigned healthy adults (18 to 50 years of age) to receive rVSVΔG-LASV-GPC or placebo intramuscularly . Participants received a single vaccine dose of 2×104 plaque-forming units (PFU), 2×105 PFU, 2×106 PFU, or 2×107 PFU or placebo or received two vaccine doses of 2×107 PFU or placebo, within a window of 6 to 20 weeks. The side-effect profile was assessed according to the incidence of solicited and unsolicited adverse events (primary end point). Because Lassa fever can cause sensorineural h...

  Abstract Influenza virus is transmitted via respiratory expulsions, but detection of infectious virus in such expulsions has been challenging . Here, we describe quantification and genotyping of infectious virus in respiratory particles using a Modular Influenza Sampling Tunnel (MIST). The particles deposit on cell monolayers , enabling culture, quantification, and sequencing of viruses. Concomitantly, water-sensitive paper and fine particle samplers yield respiratory particle counts over a broad size range. Using the MIST, we captured infectious virus from humans experimentally infected with influenza virus on multiple days post-inoculation . The recovered respiratory particles varied in quantity over three orders of magnitude and contained viral genetic variation that was also detected in samples from infected individuals. Expulsion of infectious virus was associated with infectious viral load in saliva and nasopharyngeal swabs and with clinical symptoms . These data reveal the...

  A sudden increased mortality in a commercial turkey flock. Samples were collected and submitted to the Irish Central Veterinary Research Laboratory for avian influenza testing. On 4th November 2025 highly pathogenic avian influenza sub. H5N1 was confirmed by the national reference laboratory. Source: WOAH,  https://wahis.woah.org/#/in-review/6976 ____

  {By Lukasz Lukasik - The uploader on Wikimedia Commons received this from the author/copyright holder., CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=816655 } {Isle of Man} 1 wild bird (common buzzard) was found dead on 27/10/2025. Official samples were taken and tested positive for HPAI H5N1. Source: WOAH,  https://wahis.woah.org/#/in-review/6977 ____

  Summary Kyasanur Forest disease is a neglected tick-borne viral haemorrhagic fever endemic to India's Western Ghats , caused by the Kyasanur Forest disease virus , a flavivirus transmitted by Haemaphysalis spinigera ticks . The virus circulates in a sylvatic cycle among monkeys, rodents, shrews, birds, and ixodid ticks , and is transmitted to humans incidentally via tick bites . Since its discovery in 1957 in Karnataka , Kyasanur Forest disease has spread to other Indian states, driven by deforestation , forest fragmentation , and increased human incursion into wildlife habitats . Clinically, the disease manifests in a biphasic pattern , with haemorrhagic and neurotropic presentations . Although a formalin-inactivated vaccine is available , its efficacy is not promising, and no antivirals have been approved to date. Field reports indicate that mortality in monkeys might serve as an early indicator of forthcoming human outbreaks. The transmission dynamics of Kyasanur Forest diseas...