ETIDIOH - NEW

  {Excerpt} (...) COVID-19 current vaccine safety status and insights   -- Since 2021, GACVS has regularly reviewed the safety of COVID-19 vaccines , including through global pharmacovigilance data and dedicated reviews of myocarditis, pregnancy outcomes and other adverse events of special interest (AESI).  -- The most recent updates reaffirmed that the benefits of vaccination outweigh the risks across all groups and advised continued monitoring for younger males and follow-up of persons who have reported vaccine-associated myocarditis .  -- Many individuals have received three or more doses of COVID-19 vaccine.  -- Some adverse events – such as myocarditis – seem to occur mainly after the second dose of mRNA COVID- 19 vaccines.  -- However, the outcomes were less severe in persons who developed myocarditis after vaccination compared to those unvaccinated and following infections, including SARS- CoV-2.  -- Also, children under six months of age seem t...

  {Excerpt} Time Period: February 22, 2026 - February 28, 2026 -- H5 Detection :  9 site(s) ( 2.0% ) -- No Detection :  443 site(s) ( 98.0% ) -- No samples in last week :  147 site(s) (...) Source:  Link:  https://www.cdc.gov/nwss/rv/wwd-h5.html ____

  Backyard poultry in the Bijelo Polje Region. Source:  Link:  https://wahis.woah.org/#/in-review/7334 ____

  Abstract The development of broadly protective and dose-sparing influenza vaccines remains a critical challenge , particularly for zoonotic H5N1 strains with pandemic potential . This study evaluates BECC470s, a synthetic TLR4 adjuvant , for its ability to enhance the immunogenicity and protective efficacy of recombinant H5 hemagglutinin (rHA) vaccination in murine models . BECC470s-adjuvanted rHA elicited robust IgG1/IgG2a antibody responses and complete survival following homologous 2004 H5N1 challenge in a prime–boost model . Although BECC470s broadened antibody binding to both variable HA head and conserved stalk domains by ELISA, functional neutralizing antibody responses were restricted to the matched 2004 H5N1 isolate, with no detectable neutralization of H5N1 viruses isolated in 2022 or 2024. These data indicate that BECC470s enhances the magnitude and apparent breadth of binding antibody responses while maintaining strain-specific neutralizing activity, supporting its po...