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Showing posts from March 14, 2026

#Immunity to #hemagglutinin and #neuraminidase results in additive reductions in #airborne #transmission of #influenza #H1N1 virus in #ferrets

  Abstract Currently, there is limited knowledge on the impact of immunity to hemagglutinin (HA) and/or neuraminidase (NA) on the transmission of influenza viruses . Therefore, using intramuscular vaccination , intranasal vaccination , or infection with reassortant viruses , we induced immunity to each antigen alone or both antigens combined in ferrets . We then assessed transmission of the 2009 pandemic H1N1 virus from these ferrets to naĂ¯ve respiratory contacts . For all strategies used to induce immunity, combined immunity to HA and NA resulted in the largest reductions in transmission . Moreover, immunity to HA and NA conferred additive rather than synergistic reductions in transmission. No escape variants emerged in our transmission studies, and logistical regression showed that the probability of transmission was less than 50% when viral titers in donors were reduced to 101.5 and 102 median tissue culture infectious dose per ml on days 1 and 3 postinfection, respectively. The...

History of Mass Transportation: The California Western Railroad #45 Steam Locomotive

  By Baldwinlocomotiveworks - R.A. Sallinen III - Own work, CC BY-SA 3.0,  https://commons.wikimedia.org/w/index.php?curid=18159992 Source:  Link:  https://en.wikipedia.org/wiki/Baldwin_Locomotive_Works ____

#Coronavirus Disease Research #References (by AMEDEO, March 14 '26)

  Antiviral Res ZHANG J, Deng S, Zhang M, Wu X, et al Porcine epidemic diarrhea virus infection activates SREBP2 and induces RORgamma expression to enhance cholesterol biosynthesis and virus replication. Antiviral Res. 2026 Mar 6:106391. doi: 10.1016/j.antiviral.2026.106391. PubMed           Abstract available Clin Infect Dis KHADER K, Haroldsen C, Stevens V, Visnovsky L, et al Estimating changes in facility MRSA infection rates due to changes in MRSA precaution policy. Clin Infect Dis. 2026 Mar 13:ciag176. doi: 10.1093. PubMed           Abstract available Int J Infect Dis LUGTU EJ, Iv DYP, Cabunoc MH, Bautista JL, et al Prevalence of Post-COVID Symptoms Across Variants of Concern and Follow-up Periods: A Systematic Review and Meta-Analysis. Int J Infect Dis. 2026 Mar 10:108522. doi: 10.1016/j.ijid.2026.108522. PubMed           Abstract available TANG X, Memedi M,...

#Influenza and Other Respiratory Viruses Research #References (by AMEDEO, March 14 '26)

  Ann Intern Med LALANI HS, DiResta R, Baron RJ, Scales D, et al Addressing Viral Medical Rumors and False or Misleading Information. Ann Intern Med. 2023 Jul 18. doi: 10.7326/M23-1218. PubMed           Abstract available Antimicrob Agents Chemother ZHENG X, You X, Liu Y, Wu B, et al Spatiotemporal dynamics and multiple driving factors of antimicrobial resistance in China during the COVID-19 pandemic (2019-2023): a provincial panel data analysis. Antimicrob Agents Chemother. 2026 Feb 9:e0160025. doi: 10.1128/aac.01600. PubMed           Abstract available Antiviral Res ZHANG T, Wang ZL, Li XY, Luo RH, et al Onvansertib and vilazodone inhibit SARS-CoV-2 replication via suppression of METTL3 RNA-m(6)A enzymatic activity. Antiviral Res. 2026 Feb 19:106376. doi: 10.1016/j.antiviral.2026.106376. PubMed           Abstract available YURGELONIS I, Rai DK, Li Z, Washington ...